Adjustable Soft Robotic Sleeve Mimics Complex Hemodynamics of Aortic Stenosis

Sophisticated in vivo modeling can enhance device development and therapy testing

22-HVI-3200902 – CQD 650×450

A soft robotic device, fitted around the ascending aorta in a living swine, enables high-fidelity simulation of hemodynamics and biomechanics of aortic stenosis and congenital aortic valve anomalies. The cuff-shaped sleeve — which can be personalized based on a patient’s MRI or CT data — has the potential to serve as a model for testing therapies and guiding clinical management. The system was created by a team of biomedical engineers, imaging experts and cardiovascular clinicians and is described in Nature Biomedical Engineering (2022;6[10]:1134-1147).

Advertisement

Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services. Policy

“Our highly tunable and customizable sleeve realistically recapitulates the hemodynamics of calcific aortic stenosis and congenital valve disease,” says the article’s corresponding author, Christopher Nguyen, PhD, Director of MRI Research in Cleveland Clinic’s Heart, Vascular & Thoracic Institute. “The ability to closely recreate patient-specific conditions paves the way toward developing personalized approaches to better understand and treat aortic stenosis.”

Soft robotics enable better physiological modeling

So-called soft robotics — i.e., technologies using pliable materials with qualities similar to biological tissues — can be designed to mimic biomechanical function and complex motion dynamics of various organs and systems. They are increasingly being developed as models of human physiology and disease. Dr. Nguyen previously led a team to create a soft robotic heart model that simulates contractile motion with the potential for use in preclinical testing of cardiac devices (Sci Robot. 2020;5[38]:eaay9106).

However, existing preclinical models of aortic stenosis are simplistic, often consisting of a rubber tube with sutures tightened around it to simulate the constriction of vessel stenosis. Such systems do not account for complex flow patterns caused by different configurations of the aortic valve, pulsatile valvular movement and other natural mechanisms of physiological change that occur within a living being.

This current study reports on the development of a more advanced in vivo model that functions in a living swine with information from CT, 4D MRI and other tools to more accurately recreate the hemodynamics of aortic stenosis resulting from calcific aortic valve or congenital valve disease.

Sleeve design and functionality

The sleeve, which fits as a band around the ascending aorta, consists of two thermoplastic polyurethane sheets heat-sealed together, formed with a 3D printer to contain three empty pockets. “We realized that achieving biomimicry of the native aortic valve anatomy through our sleeve design was critical to recapitulate aortic stenosis with high fidelity,” says lead author Luca Rosalia, a graduate student in the Health Sciences and Technology program of Harvard and the Massachusetts Institute of Technology (MIT).

Each pocket of the sleeve is expandable and customizable by pumping in water or air. When wrapped around the swine aorta with the pockets facing inward, the device mimics the trifold shape of an aortic valve (or the shape of a unicommissural or bicommissural valve by inflating only one or two of the pockets). The pockets are each connected to an actuation line to enable varying volume and pressure parameters, allowing for the recreation of realistic, individualized hemodynamics. “Being able to re-create congenital defects and to finely control associated hemodynamics is an incredible leap forward in the development of high-fidelity test beds of cardiovascular disease,” notes co-author Rosalia.

Advertisement

“Beyond this exemplar, we envision using tunable soft robotic tools to recapitulate the mechanics and hemodynamics of various cardiovascular diseases in the lab (in vitro) and in preclinical models,” adds Ellen Roche, PhD, Professor at MIT, who served as co-senior author on the study with Dr. Nguyen. “By bolstering these models with computational simulations, we can characterize and reproduce patient-specific mechanics and flows and assess the potential effects of various types of intervention pre-procedurally.”

Prototype soft robotic sleeve from orthoscopic view (top left) and MRI cross-section (top right). First echo functional measurements (bottom) show that the flow across the stenosis dynamically mimics aortic flow.

Study of the sleeve’s functionality in swine models demonstrated excellent concordance with human aortic stenosis flow, as assessed by 4D blood-flow velocity profiles associated with aortic stenosis, 2D cine MRI imaging, 2D velocity vector mapping, left ventricle catheterization and transepicardial echocardiography.

Orthoscopic video of the robotic sleeve in a pulsatile flow loop.

The team also used CT data to obtain aortic stenosis morphology to design a sleeve with patient-specific parameters. Using only CT data makes the system potentially more applicable to general clinical practice, Dr. Nguyen explains. Comparing outcomes with those using an available commercial device and a nonspecific sleeve (not based on patient parameters) showed that the CT-based sleeve yielded the most accurate aortic stenosis morphology.

Translational applications

Dr. Nguyen foresees multiple applications of the aortic stenosis sleeve model:

Advertisement
  • Preclinical testing. The ability to test new devices or drug therapies for aortic stenosis on a realistic animal model can shorten the time to clinical trials. Dr. Nguyen envisions creating a single device incorporating parameters from dozens of patients, making it more generalizable as a model for preclinical testing. “If we knew from our model that a new experimental valve could work in 50 people, for example, we could more quickly proceed to human trials,” he explains.
  • The model can be used for advanced training in valve repair and replacement, by exposing less-experienced surgeons to a variety of anatomical configurations and allowing practice on finding solutions.
  • Creation of custom-made devices. For a patient with complex anatomy who is unlikely to benefit from a commercially available valve, the robotic sleeve can be customized to the patient’s anatomy and then used to test different devices before implantation. “A customized sleeve can be created for an individual patient with information obtained from a doctor’s office,” says Dr. Nguyen. “I expect that the sleeve can be created in-house at large facilities — such as Cleveland Clinic, which has a 3D printer and other needed technological capabilities — or be used by smaller practices in conjunction with a partnering device manufacturer.”

Dr. Nguyen adds that his team’s advancement of soft robotics technology can serve as groundwork for others in developing more realistic and dynamic in vivo models of other cardiovascular conditions and other organ systems.

Additional perspectives

“This body of work reflects an exciting integration of multimodality imaging, computational modeling and biomimetic soft robotics that has resulted in this innovative platform with potential clinical implications,” says Deborah Kwon, MD, Director of Cardiac MRI at Cleveland Clinic, who was not involved in the study. “For example, this platform could augment evaluation of patients with bicuspid aortic valves and severe aortic stenosis who are being considered for transcatheter aortic valve replacement (TAVR). Bicuspid aortic valves are associated with eccentric and complex anatomy, and varying bicuspid valve phenotypes are associated with important imaging features that are unique to each patient. In view of that, this platform could help optimize pre-procedural planning for patients with bicuspid aortic valves in whom TAVR is being considered.”

“The study nicely showcases how multidisciplinary biomedical engineering technologies such as biomechanical device design, advanced medical imaging, 3D printing and computational modeling can synergistically work together,” adds D. Geoffrey Vince, PhD, Chair of the Department of Biomedical Engineering in Cleveland Clinic’s Lerner Research Institute. “I applaud Dr. Nguyen, Dr. Roche and team in pushing the boundaries of designing a patient-specific soft robotic sleeve based on medical imaging data allowing for more realistic hemodynamic profiles in their porcine model of aortic stenosis.”

Related Articles

patient in ICU
Cleveland Clinic and Purdue Seek to Revolutionize Intensive Care Through AI

Investigators are developing a deep learning model to predict health outcomes in ICUs.

24-NEU-4528160-genetics-parkinson-disease-650×450
Multi-Ancestry Genetic Study of Parkinson’s Disease Identifies New Risk Genes in Pursuit of Novel Treatment Targets

International collaboration is most genetically diverse study of the disease to date

23-NEU-4357266-stock-brain-image_650x450
Noninvasive Technology Enhances Ability to Map Brain Activity to Track Behavior Change

Preclinical work promises large-scale data with minimal bias to inform development of clinical tests

23-NEU-4189360-hydrogen-sulfide-650×450
Can Boosting Hydrogen Sulfide Bolster Standard-of-Care Glioblastoma Therapy to Extend Survival?

Cleveland Clinic researchers pursue answers on basic science and clinical fronts

23-NEU-4390509-CQD-Hero-650×450
Microglial Immunometabolism Endophenotypes Implicated in Sex Differences in Alzheimer’s Disease

Study suggests sex-specific pathways show potential for sex-specific therapeutic approaches

23-CCC-4375928 Quantum Innovation Catalyzer 650×450
A Unique Opportunity to Explore Quantum Computing’s Potential

Cleveland Clinic launches Quantum Innovation Catalyzer Program to help start-up companies access advanced research technology

Light trails coming from African American’s head
Blood-Based Biomarkers for Alzheimer’s Disease in Women (Podcast)

Research project aims to pinpoint biomarkers that could speed diagnosis

23-NEU-4216627_researcher-in-lab_650x450
An All-Fronts Approach to Understanding and Overcoming Alzheimer’s Disease

A conversation with Feixiong Cheng, PhD, about his wide-ranging research initiatives

Ad