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The neuroactive steroid significantly reduces seizures related to CDKL5 deficiency disorder
Integrates genetic and clinical data to distinguish from GEFS+ and milder epilepsies
Randomized trial will follow 1,000 patients to explore potential adjunctive role
Consider 36-hour standard, with certain risk factors prompting longer or shorter windows
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Machine learning models shown to accurately separate lesions from normal brain, distinguish lesion subtypes
But such EEG findings should not preclude tapering of antiseizure medications
International registry study finds SEEG involves less morbidity, greater chance of seizure freedom
Registry-based PASSION initiative aims to identify epileptogenesis biomarkers, compare therapies
Clinical/quantitative model aids in determining surgical candidates
Bottom-of-sulcus cortical dysplasia is easy to miss without advanced imaging
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