A multidisciplinary team of researchers from Lerner Research Institute has been awarded a five-year, $2.4 million grant from the National Institute of Diabetes and Digestive and Kidney Diseases (part of the National Institutes of Health) to conduct the first-ever comprehensive analysis of the human bladder and ureter throughout the lifespan.
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Non-cancerous urologic diseases (e.g., urinary tract infections, urinary incontinence and painful bladder syndrome) affect individuals of all ages, can lead to significant disability and decreased quality of life and cost more than $5 billion in healthcare expenditures each year in the United States.
Novel therapies hindered by gaps in knowledge
“Development of effective novel therapies for these conditions has been hindered by our incomplete understanding of the lower urinary tract tissues at a cellular and molecular level,” says lead principal investigator Byron Lee, MD, PhD, joint staff in the Department of Cardiovascular & Metabolic Sciences and Glickman Urological and Kidney Institute.
“With this grant, we aim to generate a high-resolution transcriptome and gene regulatory dataset for healthy human ureter and bladder tissues in males and females at various ages. This will help us to construct an anatomical map of the organs that allows comprehensive understanding of their cellular and molecular characteristics during various life stages and points us closer to novel therapeutic targets.”
Using tissue samples from donors in three age groups that reflect distinct physiological states of lower urinary tract function, the researchers will collect data from five anatomic locations with unique tissue structures and functions. They then will use these data to analyze the lineage relationships between the different cell types, validate novel markers for each cell type and study underlying gene regulatory networks.
Molecular data will become a resource for future research efforts
“These molecular data will become a valuable resource to the research community and, ultimately, will support efforts in organ repair and regeneration,” said Dr. Lee.
Angela Ting, PhD, associate staff in the Genomic Medicine Institute, and Oliver Wessely, PhD, associate staff in the Department of Cardiovascular & Metabolic Sciences, are also principal investigators on the grant.