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51% of patients with resectable cutaneous squamous-cell carcinoma achieved a pathological complete response and 13% achieved a pathological major response to the anti–programmed cell death 1 (PD-1) monoclonal antibody cemiplimab, according to …
A new phase 3 study has begun enrolling patients with high-risk, locally advanced cutaneous squamous cell carcinoma (cSCC) to evaluate the curative potential of adjuvant pembrolizumab. Cleveland Clinic oncologist Jessica Geiger, MD, introduced the …
The process of staging cutaneous squamous cell carcinoma (CSCC) is typically done using the American Joint Commission on Cancer (AJCC) and Brigham and Women’s Hospital (BWH) tumor classification systems and is based on tumor …
… cohorts.Clinical significanceBased on their findings, the research team argues that S-ITM should be codified in cutaneous squamous cell carcinoma staging systems, similar to what has been done in Merkel cell carcinoma and melanoma …
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… with the most effective course of treatment.Rethinking resectionSurgical resection is the standard of care for advanced cutaneous squamous cell carcinoma, but it would have been a major undertaking in this case. “By this point …
Immunosuppressed patients with lower-risk cutaneous squamous cell carcinoma (cSCC) who score higher on the 40-gene expression profile (40-GEP) biomarker test are at greater risk of recurrence, according to a study presented by …
Adjuvant pembrolizumab did not significantly improve progression-free survival compared with placebo in patients with high-risk, locally advanced, cutaneous squamous cell carcinoma (cSCC) following surgery and radiation, according to a Cleveland Clinic-led randomized …
… radiation therapy for pediatric metastatic osteosarcoma (Abstract #64037)Use of 40-Gene Expression Profile (40-GEP) in cutaneous squamous cell carcinoma patients at high risk of metastasis (Abstract #64578)“A major direction in radiation oncology …
by Anthony Fernadez, MD, and Christie Warren, MDNote: This is an abridged version of an article originally published in the Cleveland Clinic Journal of Medicine.Biologic therapies have revolutionized medicine and offer targeted therapy for …
By Atul Mehta, MDAs use of lung transplant (LT) becomes more common, pulmonologists should be aware of post-transplant dermatologic complications. In a recent pictorial review in CHEST, my colleagues and I describe the pathogenesis …
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