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Search Results for: cutaneous squamous cell carcinoma

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October 7, 2022/Cancer/Research

Cutaneous Squamous-cell Carcinoma Study Finds Complete Response to Immunotherapy in More than Half of Patients

51% of patients with resectable cutaneous squamous-cell carcinoma achieved a pathological complete response and 13% achieved a pathological major response to the anti–programmed cell death 1 (PD-1) monoclonal antibody cemiplimab, according to …

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June 3, 2019/Cancer/Research

Could Immunotherapy Help Cure Cutaneous Squamous Cell Carcinoma?

A new phase 3 study has begun enrolling patients with high-risk, locally advanced cutaneous squamous cell carcinoma (cSCC) to evaluate the curative potential of adjuvant pembrolizumab. Cleveland Clinic oncologist Jessica Geiger, MD, introduced the …

Squamous Cell carcinoma under microscopy
December 2, 2021/Cancer/Radiation Oncology

Study Identifies Prognostic Subgroups in Cutaneous Squamous Cell Carcinoma

The process of staging cutaneous squamous cell carcinoma (CSCC) is typically done using the American Joint Commission on Cancer (AJCC) and Brigham and Women’s Hospital (BWH) tumor classification systems and is based on tumor …

skin cancer
May 26, 2023/Cancer/Research

Study Supports Updates to Staging Systems for Cutaneous Squamous Cell Carcinoma

… cohorts.Clinical significanceBased on their findings, the research team argues that S-ITM should be codified in cutaneous squamous cell carcinoma staging systems, similar to what has been done in Merkel cell carcinoma and melanoma …

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advanced skin cancer
May 11, 2023/Cancer/Innovations

Immunotherapy a Game Changer for Case of Advanced Cutaneous Squamous Cell Carcinoma

… with the most effective course of treatment.Rethinking resectionSurgical resection is the standard of care for advanced cutaneous squamous cell carcinoma, but it would have been a major undertaking in this case. “By this point …

Squamous cell carcinoma cells
October 3, 2024/Cancer/Radiation Oncology

When to Pursue More Aggressive Treatment for Patients with T1-2a Cutaneous Squamous Cell Carcinoma

Immunosuppressed patients with lower-risk cutaneous squamous cell carcinoma (cSCC) who score higher on the 40-gene expression profile (40-GEP) biomarker test are at greater risk of recurrence, according to a study presented by …

Squamous cell carcinoma
June 2, 2025/Cancer/News & Insight

Adjuvant Immunotherapy in High-Risk Cutaneous Squamous Cell Carcinoma

Adjuvant pembrolizumab did not significantly improve progression-free survival compared with placebo in patients with high-risk, locally advanced, cutaneous squamous cell carcinoma (cSCC) following surgery and radiation, according to a Cleveland Clinic-led randomized …

Radiation therapy
September 17, 2024/Cancer/Research

ASTRO 2024 Highlights

… radiation therapy for pediatric metastatic osteosarcoma (Abstract #64037)Use of 40-Gene Expression Profile (40-GEP) in cutaneous squamous cell carcinoma patients at high risk of metastasis (Abstract #64578)“A major direction in radiation oncology …

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August 17, 2020/Cancer

Cutaneous Adverse Effects of Small-Molecule Tyrosine Kinase Inhibitors

by Anthony Fernadez, MD, and Christie Warren, MDNote: This is an abridged version of an article originally published in the Cleveland Clinic Journal of Medicine.Biologic therapies have revolutionized medicine and offer targeted therapy for …

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Squamous Cell Carcinoma of the Skin after Lung Transplant

By Atul Mehta, MDAs use of lung transplant (LT) becomes more common, pulmonologists should be aware of post-transplant dermatologic complications. In a recent pictorial review in CHEST, my colleagues and I describe the pathogenesis …

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