Studying the relationship between autism spectrum disorder and cancer in individuals affected by PTEN hamartoma tumor syndrome is the subject of a new $2 million grant awarded from the National Institutes of Health to Charis Eng, MD, PhD, Chair of the Genomic Medicine Institute.
Mapping Out the Genitourinary Microbiome
Despite increased interest in the human microbiome, information on the microbiome and urologic pathologies remain relatively limited. Researchers are hoping to change that.
Germline Genomic Profiles of Children, Adolescents and Young Adult with Solid Tumors Inform Management and Treatment
Researchers demonstrate the value of genetics evaluation and genetic testing in children, adolescents and young adults with solid tumors. Charis Eng, MD, PhD, gives insight into the largest-to-date evaluation of germline mutations in this population.
Predicting Cancer Versus Autism Risk in Patients With PTEN Mutations
New research indicates that certain metabolites, such as fumarate, may serve as predictive biomarkers that could distinguish patients with PTEN mutations who will develop neurodevelopmental disorders from those who will develop cancer.
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Genetic Status and Clinical Management of Bilateral Pheochromocytoma
A new study confirms that cortical-sparing surgery can be a safe option for patients with genetic disease, who are at greater risk for developing subsequent tumors. In this article, Charis Eng, MD, PhD, explains the research and its implications for clinical management.
New Grant Will Advance Breast Cancer Microbiome Research
A new $1.6 million Gray Foundation grant will enable cancer genetics expert Charis Eng, MD, PhD, and colleagues to advance their promising preliminary research into the breast microbiome’s role in cancer risk, development and progression.
Visualizing PTEN: Seeing Mutations Differently
Cleveland Clinic’s Genomic Medicine Institute is looking at the use of sophisticated 3-D modeling to help discern nuanced but important structural differences between germline PTEN variants associated with and predictive of a patient’s clinical condition.
Dr. Eng Receives Prestigious Medal of Honor from American Cancer Society
Cleveland Clinic’s Charis Eng, MD, PhD, received the American Cancer Society’s 2018 Medal of Honor for clinical research. Dr. Eng is acclaimed for linking certain genetic mutations to cancer risk.
The Microbiome in PTEN Hamartoma Tumor Syndrome
A new study provides initial evidence that differences in gut microbiota composition may indicate whether or not a PHTS patient will develop cancer.
The Breast Microbiome
A study comparing healthy and malignant breast tissue found more Methylobacterium in malignant breast tissue.