New model demonstrates lifesaving capabilities of next-generation sequencing for patients with non-squamous non-small cell lung cancer
Optimizing Care for Those With Genetic Predisposition to Ovarian and Breast Cancer
Patients who have a higher risk of developing breast and ovarian cancer can benefit from care that delivers consistent messaging and a unified approach.
Distinct PHTS-related Breast Cancer Genomic Characteristics Discovered
PHTS-associated breast cancers have distinct mutations from sporadic breast cancers.
Tumors with Specific Genetic Mutations Show Response to Immune Checkpoint Blockade Therapy
New research demonstrates that some immunotherapy drugs are more effective for cancers with certain genetic mutations.
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Biopsy and Adjuvant Therapy May Help Improve Mortality Rate in Uveal Melanoma
A recent study has shed new light on cure rates in uveal melanoma, presenting a clearer — although not necessarily brighter — view of the lifesaving potential of ocular treatment.
Mosaicism and TNFR-Associated Periodic Syndrome (TRAPS)
Both this and the only other case ever reported suggest that postzygotic mutations may cause TRAPS phenocopies in adulthood, offering yet another clue into the genesis of autoinflammatory disorders.
Study Finds Common Genetic Mutations in Dilated and Peripartum Cardiomyopathies
A major multicenter study has yielded the first evidence that peripartum cardiomyopathy shares genetic variants with dilated cardiomyopathy. A co-investigator discusses the implications.
Genetic Mutations Discovered That Drive Inherited Leukemias in Older Patients
Most cases of adult myeloid neoplasms, including myelodysplastic syndromes (MDS), have been presumed to occur sporadically. But Cleveland Clinic researchers identified a mutated gene, DDX41, associated with development of MDS, supporting the prospect of a familial predisposition mechanism behind such malignancies.