Locations:
Search IconSearch
March 26, 2021/Transplant

Access to Kidney Transplantation Unchanged Over 20 Years

New interventions and policies haven’t increased wait-listing

650×450-Kidney-Transplant-Access

Access to kidney transplantation today is as limited as it was 20-plus years ago despite numerous efforts to expand it.

Advertisement

Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services. Policy

According to a study recently published in the Journal of the American Society of Nephrology (JASN), the rate at which patients with end-stage renal disease (ESRD) were placed on the transplant waitlist was unchanged between 1997 and 2016. So was the disparity in transplantation access between patients with lower-income, minority status and other vulnerability factors, and their counterparts.

“Access to kidney transplantation has been a problem that has permeated my research career,” says Cleveland Clinic biostatistician Jesse Schold, PhD, lead author of the study. “We’d like to assume that things are getting better, with at least incremental progress over the decades. But the results of this study were striking, showing that we have made no progress at all.”

That’s not to say there hasn’t been ample effort. Numerous policy changes and interventions have attempted to help overcome or sidestep barriers to wait-listing patients with ESRD. While some individual efforts have been promising, their combined effect has been nil.

The JASN study is the first to evaluate the cumulative effect of interventions over an extended period.

Holding steady at under 30%

“Kidney transplantation has significant benefits for patients with ESRD, including doubling life expectancy and improving quality of life,” says Cleveland Clinic nephrologist Emilio Poggio, MD, senior author of the study. “It also has been shown to reduce healthcare costs when compared to maintenance dialysis.”

To review the long-term pattern of access to this gold-standard treatment, a research team led by Drs. Poggio and Schold studied the U.S. Renal Data System records of 18- to 70-year-olds who were diagnosed with ESRD, were placed on a transplant waitlist or received a kidney transplant between 1997 and 2016. The cohort included more than 1.3 million patients. Researchers assessed time to wait-listing or kidney transplantation from time of diagnosis and found:

  • Incidence of wait-listing or transplant within four years of diagnosis was 29.7% — and did not change throughout any of the five eras evaluated (1997-2000, 2001-2004, 2005-2008, 2009-2012 and 2013-2016).
  • Incidence of wait-listing or transplant was substantially lower among patients in lower-income communities — and did not improve over time.

Advertisement

One positive finding was that preemptive wait-listing or transplant (prior to starting dialysis) did increase over time, from 5.2% in 1997-2000 to 9.8% in 2013-2016.

“Overall, these results were discouraging,” says Dr. Schold. “Even though many ad hoc interventions have been effective, they haven’t been sustainable or generalizable, and thus haven’t impacted the broader population.”

Wait-list barriers are systemic

The barriers to wait-listing are systemic, says Dr. Schold. The promise of new interventions has been countered by a complex system that involves multiple patient handoffs and requires a higher level of health literacy for patients to navigate the steps for wait-listing.

“This calls for more substantial action that has a more profound effect on our entire system of care,” he says.

The Advancing American Kidney Health Initiative, an executive order issued in 2019 by former President Donald Trump, is a good start. Federal backing to increase transplant accessibility and modernize the transplant program may help move the needle.

Dr. Schold recommends considering an “opt-out” model for transplant referral, at least for patients with ESRD who don’t have contraindications to transplant and likely will meet clinical transplant criteria.

“Instead of requiring a proactive step, referral for evaluation at a transplant center should be automatic — bypassing any barriers inherent in the system,” he says. “Our study included only patients who had been referred for transplant, but there likely were many more who should have been referred but weren’t.”

Advertisement

Related Articles

23-URL-3973558 CQD 650×450-B
July 11, 2023/Transplant
Moving Closer Toward Narcotic-Free Kidney Transplantation

Smaller incision may lead to reduced postoperative pain for some patients

Masked Medical Appointment
March 21, 2022/Transplant
Pilot Study to Create Automated Referral Process for Kidney Transplants

The process could improve access and equity for patients with end-stage kidney disease

650×450-Covid-and-Kidneys
September 7, 2021/Transplant
Early Successes in Kidney Transplantation From Deceased Donors With COVID-19

Infectious disease and kidney transplant specialists share key insights

650×450-Dialysis-Safety-Wong
September 2, 2021/Transplant
Many High-Priority Patients Not Placed on Kidney Transplant Waitlist

Demographic and social factors found to influence preemptive listing

650×450-SPSurgery
November 5, 2019/Transplant
First Kidney Transplant Performed in the World Using Single-Port Robot

Cleveland Clinic surgeons use single-incision robotic surgery to perform kidney transplant

16-TRC-1010-Transplant-CQD-650×450
December 7, 2018/Transplant
Pushing the Limits of Organ Transplant

Transplant Center makes more organs available to more patients

Ad