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Genomic Medicine

DNA

Is the MTHFR Gene Mutation Associated With Thrombosis?

The relationship between MTHFR variants and thrombosis risk is a complex issue, but current evidence points to no association between the most common variants and an elevated risk

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Microglial Immunometabolism Endophenotypes Implicated in Sex Differences in Alzheimer’s Disease

Study suggests sex-specific pathways show potential for sex-specific therapeutic approaches

Feixiong Cheng, MD

An All-Fronts Approach to Understanding and Overcoming Alzheimer’s Disease

A conversation with Feixiong Cheng, PhD, about his wide-ranging research initiatives

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October 27, 2023/Genomic Medicine

Cleveland Clinic Treats First Patient With Investigational Gene Therapy for Hypertrophic Cardiomyopathy

One-time infusion of adenovirus-based therapy is designed to restore heart muscle function

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Genetic testing
June 16, 2023/Bioethics

The Cost of ‘Free’: Advising Patients About Sponsored Genetic Testing

Authors discuss ethical challenges associated with sponsored genetic testing

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Quantum Computing Debuts at Cleveland Clinic

Discovery Accelerator Partnership with IBM Deploys Advanced Computing Technologies to Supercharge Healthcare Research

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February 22, 2023/Genomic Medicine/Research

Determining Autism, Cancer Risk in Patients with PTEN Hamartoma Tumor Syndrome

Cleveland Clinic researchers receive $2 million grant from the National Institutes of Health

Brain research

Deep Learning Framework Unveiled for Identifying Risk Genes and Drug Targets in Alzheimer’s Disease

Open-source artificial intelligence technology uses human genetic data to find candidate drugs

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Transcriptomics-Based Study Suggests Metformin Is Repurposable for Atrial Fibrillation

Network proximity and EHR analyses identify diabetes drug as a top candidate for risk reduction

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November 17, 2022/Behavioral Health/Case Study

Altered Mental Status in a Man With Metabolic Syndrome

A case study in how pharmacogenomic testing can be helpful if not always essential

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