December 8, 2020/Neurosciences/Case Study

First Use of the Novel Monitor Mode on a Gel Pad Surface Cooling Device to Maintain Normothermia

Case report demonstrates utility in a brain-injured patient

By Brittany Cunningham, PharmD; Amanda Staudt, APRN; Amy Renner, APRN; Gregory Griffin, DO; and Christopher R. Newey, DO, MS


Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services. Policy

After neurological injury, the brain is susceptible to secondary injury from processes that increase metabolic demand, such as fever.1,2 For every 1oC increase in temperature, cerebral metabolic demand increases by 8%.3 Fever is associated with increased morbidity and mortality in patients with brain injury from multiple etiologies.1,4 The Copenhagen Stroke Study found that there was a 30% increase in mortality for every 1°C above 37°C in patients with acute ischemic stroke.5 Fevers also contribute to increased length of stay in the neurologic ICU.6

The duration of targeted temperature management varies by clinical situation. The current recommendation for out-of-hospital cardiac arrest temperature management is a minimum of 24 hours.1 This duration maybe longer in other brain injuries.1 Multiple methods can be used for temperature management. The most reliable and effective means to cool is via conduction, which is the direct transfer of heat between surfaces where the amount of heat loss is related to contact surface.1

One such conductive method is the use of a gel pad surface cooling device, which consists of hydrogel-coated pads that adhere to the patient’s midsection and thighs. Temperature-controlled water is circulated under negative pressure to maintain the core body temperature at a predetermined temperature. We report here the case of a hospitalized patient with brain injury who developed a fever requiring gel surface cooling. We maintained his temperature within a targeted range using the novel maintenance mode on a recently updated gel pad surface cooling device.

Case presentation

A 79-year-old man with a history of diabetes, hyperlipidemia and paroxysmal atrial fibrillation was admitted to our hospital with a headache and gait instability. He was taking apixaban 5 mg twice daily. He reported having fallen two weeks prior to admission.

Head CT showed a right convexity subdural hemorrhage measuring 1.2 cm with 2 mm of midline shift (Figure 1A). INR was 1.18 (normal, 0.9-1.30), partial thromboplastin time was 28.8 seconds (normal, 23.0-32.4) and platelet count was 260,000/mm3 (normal, 141,000-365,000). He was given 4,500 units of activated prothrombin complex concentrate (50 U/kg). Repeat head CT was stable. Neurologically, he had no focal deficits.


On hospital day 4, he was taken to the operating room for subdural hemorrhage evacuation. In the immediate postoperative period he was found to have increasing encephalopathy and left hemiparesis. Repeat CT head showed reaccumulation of subdural hemorrhage with 8 mm of midline shift (Figure 1B). Repeat coagulation studies and platelets again were normal.

He was taken emergently to the operating room for a second evacuation, during which he was noted to have extensive oozing from the underside of the dura. Postoperative head CT again showed reaccumulation of subdural hemorrhage with midline shift (Figure 1C). He was given fresh frozen plasma and remained comatose. Coagulation studies and platelets remained normal. Fibrinogen was 798 mg/dL (normal, 200-400), and antithrombin activity assay was 97.6% (normal, 84.0%-123.0%).

Figure 1. Head CTs at presentation, showing the right convexity subdural hemorrhage with thickness of ~1.2 cm (A), immediately after the initial subdural hemorrhage evacuation (B) and following the second evacuation (C).

On hospital day 5, he developed status epilepticus and required treatment with midazolam infusion, fosphenytoin and levetiracetam. On hospital day 6, he developed a fever of 43oC. Cultures were obtained, and he was started on antibiotics. His temperature remained elevated.

He was placed on a gel pad surface cooling device using monitor mode, with a set temperature range of 36° to 37.5°C (Figure 2). He remained on this monitor mode for four days, at which point the setting was changed to normothermia mode with a set temperature of 37°C (red arrow). During the monitor mode, the water temperature of the gel pad surface cooling device remained fairly continuous and smooth compared with the normothermia mode (after the red arrow). He remained clinically unchanged and was transitioned to hospice care.


Figure 2. Temperature tracings over time from the patient’s gel pad surface cooling device. The device’s monitoring mode was used for four days before the setting was transitioned to normothermia mode (37°C; red arrow). During the use of monitoring mode, the patient’s temperature was kept between 36° and 37.5°C with a more consistent water temperature relative to the post-monitor mode period (i.e., after the red arrow). Blue line indicates the device’s water temperature. Yellow line indicates patient temperature.

Temperature management in brain injury

This case is, to our knowledge, the first reported use of the novel monitor mode on the updated gel pad surface cooling device. This mode allows the user to set upper and lower temperature limits. It also allows the user to set a length of time during which a patient can be outside these limits. By permitting the setting of a temperature range, the new monitor mode allows for improved patient comfort. A range will reduce the water temperature fluctuations and allow for a more consistent and stable water temperature, as we have demonstrated in this case.


  1. Madden LK, Hill M, May TL, et al. The implementation of targeted temperature management: an evidence-based guideline from the Neurocritical Care Society. Neurocrit Care. 2017;27:468-487.
  2. Clifton GL, Miller ER, et al. Lack of effect of induction of hypothermia after acute brain injury. N Engl J Med. 2001;344:556-563.
  3. Wright W, Geocadin R. Postresuscitative intensive care: neuroprotective strategies after cardiac arrest. Semin Neurol. 2006;26:396-402.
  4. Nielsen N, Wetterslev J, Cronberg T, et al. Targeted temperature management at 33oC versus 36oC after cardiac arrest. N Engl J Med. 2013;369:2197-2206.
  5. Kammersgaard LP, Jorgensen HS, Rungby JA, et al. Admission body temperature predicts long-term mortality after acute stroke: the Copenhagen Stroke Study. Stroke. 2002;33:1759-1762.
  6. Dirringer MN, Reaven NL, et al. Elevated body temperature independently contributes to increased length of stay in neurologic intensive care unit patients. Crit Care Med. 2004;32:1489-1495.

Dr. Newey is Medical Director of the Neurosciences ICU at Cleveland Clinic Akron General and Medical Director of Multimodal Monitoring for Cleveland Clinic. All other co-authors are clinical providers at Cleveland Clinic Akron General.

Related Articles

September 8, 2022/Neurosciences/Case Study
Case Study: Rare Cerebrovascular Condition in a Postpartum Patient

When specialized surgery makes sense for moyamoya syndrome

August 19, 2022/Neurosciences/Case Study
Cervical Kyphosis in a Geriatric Patient: A Case Study

Multilevel cervical fusion restores function in an athletic 78-year-old

22-NEU-2918752-CQD-Hero-650×450 (1)
Laser Ablation for Unilateral Periventricular Nodular Heterotopia and Drug-Resistant Epilepsy

Case study underscores the imperative for thorough evaluation with SEEG

21-NEU-2051980 schwannoma of lacrimal nerve_650x450
April 22, 2021/Neurosciences/Case Study
Case Study: A Tumor in the No-Man’s-Land Between Eye, Nose and Brain

Schwannoma of the lacrimal nerve threatened right eye blindness

MRI showing a spinal ependymoma
Case Study: 46-Year-Old With Invasive Anaplastic Grade III Spinal Ependymoma

Partial resection plus radiation leads to good outcome from an unpredictable tumor

April 28, 2020/Neurosciences/Case Study
Head-Turning Mystery Proves No Match for Dynamic Angiography

Diagnosis and treatment of rotational vertebrobasilar insufficiency syndrome

February 14, 2020/Neurosciences/Case Study
Intracerebral Hemorrhage Removal with Endoscopic Side-Cutting Aspiration

First reported case expands use of minimally invasive techniques

November 21, 2019/Neurosciences/Case Study
Challenges of Epilepsy Surgery in an Infant with a Hemispheric Syndrome: Case Study

Much is possible when treating epilepsy in the developing brain