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Preventive Cardiology

illustrated human gut with microbes and an overlay of a rhythm tracing

TMAO Shown to Be a Modifiable Risk Factor for Atrial Fibrillation

Bench-to-bedside study identifies mechanism and potential therapeutic target

human intestines with inset showing gut microbes

TMAO Emerges as a Biomarker for AAA Risk

Elevated levels of the gut microbial metabolite predict prevalence and adverse outcomes in community-based study

stylized illustration of cholesterol particle floating in bloodstream

Novel siRNA Produces Deep, Durable Reduction in Lp(a)

Phase 1 trial shows up to 97% decrease through 48 weeks with good tolerability

converging lines on a graph pointing downward

Oxidized Phospholipids Track Closely With Lp(a) Reductions in Clinical Trial

Post hoc ALPACA analysis boosts biological rationale for ongoing outcomes trial of lepodisiran

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sight picture overlaid on DNA double helix

Positive Effects of CRISPR-Cas9 Gene Editing for Dyslipidemia Endure Through 1 Year

Durability findings propel potential one-time treatment approach to phase 1b testing

illustrated platelets forming a clot in a blood vessel

Bempedoic Acid Appears to Curb VTE Risk in Statin-Intolerant Patients

Post hoc analysis of CLEAR Outcomes trial bolsters its case as a statin alternative

doctor taking pulse of a woman in an exam room

Counseling Patients on the New Cholesterol Guideline: What Providers Should Know

How to talk about lifetime risk, treatment goals, Lp(a) testing, statin skepticism and more

stylized scientific illustration of hormone receptors

Dual-Agonist Incretin Therapy Outshines GLP-1 Agonist in Broad Cardiorenal Outcomes

Post hoc analysis of SURPASS-CVOT trial has implications for future cardiovascular outcome trials

LDL cholesterol particle with a DNA double helix on top of it

CRISPR-Cas9 Gene Editing for Refractory Dyslipidemia Shows Safety and Preliminary Efficacy

First-in-human phase 1 trial induced loss of function in gene that codes for ANGPTL3

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