A multidisciplinary team seeks to elucidate the underlying cytokine biology of Susac syndrome. In this article, rheumatologists discuss why they hope to identify new therapeutic targets for the rare condition.
A 28-year-old woman presents with a constellation of symptoms that point to an immune-mediated, occlusive microvascular endotheliopathy. In this article, retina and uveitis specialist, Sumit Sharma, MD, describes the astute workup that leads to the correct diagnosis.
Susac Syndrome primarily affects the brain, retina and inner ear. But it’s possible that it will sometimes affect other organs, including muscle or the GI tract.
An international collaborative study and disease registry are among an array of efforts led out of Cleveland Clinic to better understand and manage this rare autoimmune disease.
Arriving at a diagnosis of CNS-V is fraught with challenges. There is no classic presentation, the condition has several mimics, brain tissue is inaccessible and there is no disease-specific test. However, advances in neuroimaging and next-generation sequencing have added formidably to our knowledge of CNS-V.
Cole Eye Institute ophthalmologists are seeking to understand how an enhanced retinal imaging technology, known as ultra-widefield imaging, can clarify how to best manage patients based on the degree of ischemic burden.
For patients, visible symptoms of uveitis correlate with perceptions of worse physical health, according to a recent study. Ophthalmologist Sunil Srivastava, MD, and rheumatologists Rula Hajj-Ali, Joshua Hedrick, MD, explain the relationship between patient reported outcomes measures and disease activity in inflammatory eye disease.
Clinicians should be aware of a possible association between HS and inflammatory eye disease, perhaps arising from an immune dysregulation phenomenon similar to that which links Crohn’s and HS.
Aggressive measures are called for in cases of systemic lupus erythematosus retinal vasculitis. Without accurate diagnosis and treatments, stakes are high, including the risk of major vision loss.