NHLBI CTSN Trial Nudges Practice Toward Mitral Valve Replacement for Severe Ischemic MR

Replacement procedures surge while repairs ebb in wake of study publication

Mitral Valve Repair

U.S. surgical management of patients with severe ischemic mitral regurgitation has significantly shifted toward mitral valve replacement in the wake of the January 2014 publication of the milestone Cardiothoracic Surgical Trials Network (CTSN) study comparing mitral valve repair versus replacement in this setting. So reported investigators with the multicenter trial — known as the NHLBI CTSN trial due to its support by the National Lung, Heart, and Blood Institute — in a late-breaking abstract presentation at the annual meeting of the Society of Thoracic Surgeons (STS) on January 29, 2018.


Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services. Policy

Across 1,131 sites participating in the STS Adult Cardiac Surgery Database from 2011 through 2016, 4,440 patients underwent mitral valve surgery for severe ischemic mitral regurgitation. The 2,271 procedures performed before January 2014, when the NHLBI CTSN trial was published in the New England Journal of Medicine, broke down as follows:

  • 24.2 percent were mitral valve replacements
  • 75.8 percent were mitral valve repairs

The 2,169 procedures performed after April 2014 broke down as follows:

  • 34.8 percent were mitral valve replacements
  • 65.2 percent were mitral valve repairs

The difference in the rates of replacement versus repair between the two periods was statistically significant (P < .0001), the investigators reported at the STS meeting. Their analysis of the post-study publication period began after April (rather than January) 2014 to allow several months for the NHLBI CTSN results to be absorbed and translated to practice.

“This trial appears to be changing practice across the country,” says Cleveland Clinic Cardiothoracic Surgery Chair A. Marc Gillinov, MD, who is a co-author of the new NHLBI CTSN analysis presented at the STS meeting, along with Rakesh Suri, MD, DPhil, Acting CEO and Chair of Thoracic and Cardiovascular Surgery at Cleveland Clinic Abu Dhabi. Cleveland Clinic is a CTSN member site.


Favored approach differs from degenerative mitral disease

While mitral valve repair is the gold-standard surgical approach for degenerative mitral valve disease, the preferred approach for severe ischemic mitral regurgitation had been uncertain until publication of the NHLBI CTSN results. The randomized trial assessed the tradeoff between reduced perioperative risk with restrictive mitral valve annuloplasty and more durable correction of mitral regurgitation with chordal-sparing mitral valve replacement.

Although the study found no significant differences between repair and replacement in survival or left ventricular reverse remodeling at one-year or two-year follow-up, repair was associated with higher rates of mitral regurgitation and heart failure-related adverse events and hospital readmissions.

“It is difficult to predict which patients will have a repair that lasts,” Dr. Gillinov notes, “so replacement should be the first consideration in this patient population.”

Still more to learn

This recommendation seems to be increasingly heeded by U.S. cardiac surgeons and their patients with severe ischemic mitral regurgitation, as evidenced by the data presented at the STS meeting. That analysis also tracked one-year outcomes among the 4,440 mitral valve surgery patients evaluated from 2011 through 2016. While it showed that mortality was comparable between the periods before and after NHLBI CTSN publication, rates of heart failure-related readmissions were lower during the period after the study publication, although the reduction was not directly attributable to higher rates of replacement versus repair.


“We still have more to learn about the nuances of outcomes with each of these approaches,” says Dr. Gillinov. “Ongoing long-term analysis is warranted to refine our understanding of optimal treatment of severe ischemic mitral regurgitation.”

Related Articles

x-ray of bone fracture in a forearm
TRAVERSE Substudy Links Testosterone Therapy to Increased Fracture Risk in Older Men With Hypogonadism

Surprise findings argue for caution about testosterone use in men at risk for fracture

photo of intubated elderly woman in hospital bed
Proteomic Study Characterizes Markers of Frailty in Cardiovascular Disease and Their Links to Outcomes

Findings support emphasis on markers of frailty related to, but not dependent on, age

GettyImages-1252287413 [Converted]
Black Residents of Historically Redlined Areas Have Increased Heart Failure Risk

Large database study reveals lingering health consequences of decades-old discrimination

Study Confirms Quality-of-Life Benefits of Myectomy in Obstructive HCM

Prospective SPIRIT-HCM trial demonstrates broad gains over 12-month follow-up

21-HVI-2211308 gender-scales_650x450
8 Ways to Increase Women’s Participation in Cardiovascular Trials

An ACC committee issues recommendations to accelerate sluggish progress

Carotid Endarterectomy and the High-Risk Patient

Review of our recent experience shows it’s still a safe option