Hydrogen sulfide signaling emerged as a possible glioblastoma tumor suppressor that is highly sensitive to dysregulation by dietary fat. The findings suggest a potential role for dietary interventions that boost hydrogen sulfide bioavailability.
A preclinical study shows that inhibiting DNA-dependent protein kinase induces glioma stem cell differentiation and thereby sensitizes glioblastoma to radiation therapy.
Researchers are using low-frequency focused ultrasound with microbubble resonators to disrupt the blood-brain barrier and deliver chemotherapy to tumor cells in the brain.
Our latest Neuro Pathways podcast delves into glioblastoma research, touching on everything from single-cell RNA sequencing to sex differences and microbiome effects.
Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services Policy
A multicenter research team will investigate differences in genetics, epigenetics and cell biology between males and females, with the goal of more-personalized therapy approaches for glioblastoma.
Blocking a signaling pathway associated with the WISP1 protein may help slow glioblastoma development by disrupting maintenance of glioma stem cells and tumor-supportive macrophages.
Neuro-oncologist Manmeet Ahluwalia, MD, surveys the glioblastoma research landscape from bench studies to testing of targeted therapies, immunotherapies and more.
We profile four ongoing Cleveland Clinic-led clinical studies that are evaluating mechanistically diverse strategies to extend survival in patients with this formidable malignancy.
An early human study suggests immunotherapy for glioblastoma may require targeting the immune suppressive effects of MDSCs along with immune activation tactics to overcome tumor-induced immunosuppression.
Differentiating true glioblastoma progression from pseudoprogression is a vexing challenge with big implications for management. New research reveals the promise of taking an algorithmic approach to MRI evaluation.