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Basic & Translational Science

macrophages and microglia in glioblastoma tumors
December 3, 2024/Neurosciences/Brain Tumor

Dual Targeting of Macrophages and Microglia Shows Promise in Preclinical Glioblastoma Models

Combining dual inhibition with anti-PD1 therapy yielded >60% rate of complete tumor regression

3D maps of T2 MRIs in postmortem multiple sclerosis brains

Disability Can Be Independent of Cerebral White Matter Demyelination in Progressive MS

MRI classifier identifies a subset of patients with disease marked by cortical atrophy, not demyelination

scalp EEG electrodes on a woman's head
October 17, 2024/Neurosciences/Epilepsy

Machine Learning Algorithm May Enhance Accuracy of Predicting Seizure Control After Epilepsy Surgery

Model relies on analysis of peri-ictal scalp EEG data, promising wide applicability

Medical graphic depicting CD55 movement to cell nucleus

Nuclear CD55 Fuels Platinum Resistance in Ovarian Cancer

Researchers identify potential path to retaining chemo sensitivity

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researcher in dark laboratory
September 12, 2024/Neurosciences/Research

Preclinical Imaging Research Aims to Help Refine Deep Brain Stimulation for Stroke Recovery

$3.2 million grant will fund use of calcium-based imaging to record neuronal activity in ischemia model

gut microbes in the human intestine

Gut Microbial TMAO Pathway Associated With Incident Heart Failure

Metabolites from animal product substrates implicated in heart failure development in community cohorts

chemical structure of erythritol drawn in a teaspoon

Evidence Mounts That Sugar Substitute Erythritol Raises Cardiovascular Risk

Study authors urge reevaluation of the sweetener’s safety designation by food regulators

gut-brain axis

Assessing Alzheimer’s Disease Drug Targets Along the Gut-Brain Axis

Pairing machine learning with multi-omics revealed potential therapeutic targets

nutrition label of product containing xylitol

Another Sugar Substitute, Xylitol, Is Linked to Heightened Cardiovascular Risk

Studies reveal increased cardiac events, enhanced platelet reactivity and thrombotic potential

deep brain stimulation of dentate nucleus

Deep Brain Stimulation After Stroke: What Underlies Improved Motor Function?

EDEN analysis investigates electrophysiological changes after continuous dentate nucleus stimulation

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