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Basic & Translational Science

chemical structure of erythritol drawn in a teaspoon

Evidence Mounts That Sugar Substitute Erythritol Raises Cardiovascular Risk

Study authors urge reevaluation of the sweetener’s safety designation by food regulators

gut-brain axis

Assessing Alzheimer’s Disease Drug Targets Along the Gut-Brain Axis

Pairing machine learning with multi-omics revealed potential therapeutic targets

nutrition label of product containing xylitol

Another Sugar Substitute, Xylitol, Is Linked to Heightened Cardiovascular Risk

Studies reveal increased cardiac events, enhanced platelet reactivity and thrombotic potential

deep brain stimulation of dentate nucleus

Deep Brain Stimulation After Stroke: What Underlies Improved Motor Function?

EDEN analysis investigates electrophysiological changes after continuous dentate nucleus stimulation

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brain puzzle with piece missing and female symbol

Latest WAM Grant Recipients Take on Alzheimer’s Disease in Women Across Multiple Fronts

Awards fund research on oxidative targets, immunometabolism, spatial navigation testing and more

gut microbes in intestine

Cleveland Clinic, Tufts University Research Ties Gut Microbial TMAO Pathway to Chronic Kidney Disease

Large-scale joint study links elevated TMAO blood levels and chronic kidney disease risk over time

patient in ICU

Cleveland Clinic and Purdue Seek to Revolutionize Intensive Care Through AI

Investigators are developing a deep learning model to predict health outcomes in ICUs.

illustration of an alzheimer brain and a packet of sildenafil pills
March 11, 2024/Neurosciences/Research

Sildenafil as an Alzheimer’s Candidate Drug: Further Support From Insurance Database and Mechanistic Studies

Real-world claims data and tissue culture studies set the stage for randomized clinical testing

histology image of a gray matter lesion in a multiple sclerosis brain

Study Suggests Protective Role for Microglia at Borders of Gray Matter Lesions in Progressive MS

Findings challenge dogma that microglia are exclusively destructive regardless of location in brain

photo of grains and niacin supplement pills

Link Discovered Between Excess Niacin and Cardiovascular Disease

Newly identified pathway may explain the so-called niacin paradox

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