Dr. Maciejewski was honored for his groundbreaking genomic discoveries related to leukemia and contributions to cancer precision medicine.
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10 ASCO Presentations You Don’t Want to Miss
Cleveland Clinic shares top research abstracts to check out at the 2023 ASCO annual meeting.
Clinical and Molecular Determinants of Clonal Evolution in Aplastic Anemia and Paroxysmal Nocturnal Hemoglobinuria
Researchers seek to better understand predictors of secondary myeloid neoplasms in patients with aplastic anemia or paroxysmal nocturnal hemoglobinuria.
Paroxysmal Nocturnal Haemoglobinuria Complicated by Budd–Chiari Syndrome: A Case Study
An urgent evaluation reveals rare congestive hepatopathy in a patient with paroxysmal nocturnal haemoglobinuria.
Newly Identified Risk Factors Help Predict How Aplastic Anemia Can Become Malignant
In the largest study of its kind, researchers have identified the clinical, immunogenetic, and molecular features that characterize the evolution of aplastic anemia and paroxysmal nocturnal hemoglobinuria to myelodysplastic syndrome or acute myeloid leukemia.
Alumnus Honors His Father, His Field and His Training by Riding in VeloSano
Alumni who are passionate about patient care and medical research and looking for a fun way to support both should consider joining Joseph A. Bauer, PhD, and the rest of the VeloSano Alumni Team this year. Dr. Bauer shares why he joined the team and how important VeloSano is to cancer research at Cleveland Clinic.
Molecular and Genetic Mechanisms in Bone Marrow Failure Syndromes and Myeloid Neoplasia
Taken together, the two studies build upon a body of work dedicated to understanding the root causes, prognostic factors and optimal management of bone marrow failure syndromes and myeloid neoplasia.
Selective Targeting May Have Therapeutic Potential in TET2-Mutant Neoplasia
Treatment with a small-molecule TET inhibitor, TETi76, effectively suppresses the clonal evolution of TET2-mutant cells in mouse models and restricts the growth of TET-deficient leukemia in vivo.
Zebrafish Models Fuel Study of Pediatric Neutropenias
After having successfully created a zebrafish model to study Shwachman-Diamond syndrome (SDS), a rare inherited bone marrow failure syndrome that confers a high risk for developing myelodysplastic syndrome and acute myeloid leukemia, researchers at Cleveland Clinic are now turning their attention to other genetic disorders and cancers.
Machine Learning Improves the Subclassification and Prognostication of Acute Myeloid Leukemia
Advanced machine learning techniques will enable future research efforts aimed at discovering complex phenotype-genotype correlations and predicting population-level outcomes not just in AML, but in other fields of medical research as well.