Despite 15 years of experience with tumor necrosis factor -α inhibitor (TNFI) -induced psoriasis, our understanding of its pathogenesis remains incomplete. A recent case-control study identified risk factors and triggers associated with the onset of this condition.
Search Results for: psoriasis
TNFi-Induced Psoriasis and Idiopathic Psoriasis Can Be Distinguished on Biopsy
Is it idiopathic psoriasis or TNFi-induced psoriasis? A new study finds histological differences between these two types of psoriatic lesions that impact treatment.
10 Years of Treating TNF-α Inhibitor-Induced Psoriasis
Comanagement of TNFI-induced psoriasis in rheumatology and dermatology means better patient outcomes, according to a decade of experience at Cleveland Clinic.
Ustekinumab for Psoriasis in a Patient with HIV-Associated Kaposi Sarcoma
This is the first reported case in which an HIV-positive patient with both severe psoriasis and KS is treated with ustekinumab. The results suggest that the biologic may be a safe and effective treatment for these patients.
How Can Nail Psoriasis Be Best Managed?
How do you sort through all the emerging therapies for nail psoriasis? Dermatologist Thomas J. Knackstedt, MD, advises.
Building a Personalized Medicine Approach to PsA Treatment
Cleveland Clinic’s Orthopaedic & Rheumatologic Institute is studying genetic polymorphisms with the aim of improving the understanding of why some individuals do not respond to TNFα blockers. The ultimate goal is to find a new therapeutic approach for those with PsA.
When Edema and Dyspnea Accompany Dyschromic Nails
Dyschromic nails, lymphedema and sinus and lung symptoms point to yellow nail syndrome.
How Autoimmune Disorders Impact Myocardial Infarction Treatment and Long-Term Outcomes
Underlying rheumatic autoimmune disease was associated with reduced use of coronary interventions for MI and a 15% increase in all-cause mortality in the two years after infarction, a large analysis finds.
Advancing the Research on Selective TNF-α Inhibition in Psoriatic Disease
The Husni lab’s ongoing work in TNFR signaling in psoriatic disease has revealed that PRMT5 plays a critical role in TNF-α induction of gene expression at varying levels.
Collaborative Rheumatology-Dermatology Clinic Improves Outcomes
Co-management clinics yield improved patient outcomes and increased opportunities for research and education. In this article, rheumatologist Elaine Husni, MD, MPH, and dermatologist Anthony Fernandez, MD, PhD, discuss their new shared clinic.