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Cole Eye Institute: 2025 Highlights

Cleveland Clinic Cole Eye Institute is proud to share highlights from 2025. Read on for notable news, research insights, and more on how we support patient health and well-being.

A woman's eye next to a man's eye

Researchers Discover Differences in Protein Makeup of Male vs. Female Retinas

Preclinical study shows why it’s critical to consider sex in eye disease research

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Research and Innovations

Eye with DNA double helix
Study Is First to Reveal That Genes Causing AMD Vary by Ancestry

CFH gene triggers the eye disease in white patients but not Black patients

Child getting an eye exam
AI Model Detects Amblyopia Based on Fixational Eye Movement

It’s the first step toward reliable screening with your smartphone

Child wearing a virtual reality headset
Real-World Evidence Supports Dichoptic Therapy for Amblyopia

Registry data highlight visual gains in patients with legal blindness

Older woman with obesity and glasses
GLP-1 Agonists May Lower Risk of Age-Related Macular Degeneration

Evidence mounts that these diabetes and obesity drugs may protect eyes, not endanger them

Approaches to Managing Glaucoma

Pregnant woman in a pharmacy
Managing Glaucoma in Pregnant Patients

Prescribing eye drops is complicated by unknown risk of fetotoxicity and lack of clinical evidence

Improving Patient Care

Retina
OCT and OCT-A Can Reveal Biomarkers of Preterm Birth in Adults

Prematurity is linked with poorer outcomes of retinal surgery in adulthood

Eye with uveitis
Patients Taking GLP-1 Meds Reduce Risk of Noninfectious Uveitis by About 50%

Study is first to show reduction in autoimmune disease with the common diabetes and obesity drugs

Diabetic retinopathy
Anti-VEGF in the Real World: Who Is at Risk of Vision Loss After Lapse in Treatment?

Study identifies factors that may predict vision outcomes in diabetic macular edema

Optical coherence tomography image showing macular fluid
Real-World Results: High-Dose Aflibercept Reduces Macular Fluid, Maintains Vision in nAMD

New insights on effectiveness in patients previously treated with other anti-VEGF drugs

Neoadjuvant therapy
Novel Neoadjuvant Treatment Trial for Uveal Melanoma

Oral medication may have potential to preserve vision and shrink tumors prior to surgery or radiation

Physician Insights

Resources

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