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Cole Eye Institute: 2025 Highlights

Cleveland Clinic Cole Eye Institute is proud to share highlights from 2025. Read on for notable news, research insights, and more on how we support patient health and well-being.

A woman's eye next to a man's eye

Researchers Discover Differences in Protein Makeup of Male vs. Female Retinas

Preclinical study shows why it’s critical to consider sex in eye disease research

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Research and Innovations

Eye with DNA double helix
Study Is First to Reveal That Genes Causing AMD Vary by Ancestry

CFH gene triggers the eye disease in white patients but not Black patients

Child getting an eye exam
AI Model Detects Amblyopia Based on Fixational Eye Movement

It’s the first step toward reliable screening with your smartphone

Child wearing a virtual reality headset
Real-World Evidence Supports Dichoptic Therapy for Amblyopia

Registry data highlight visual gains in patients with legal blindness

Older woman with obesity and glasses
GLP-1 Agonists May Lower Risk of Age-Related Macular Degeneration

Evidence mounts that these diabetes and obesity drugs may protect eyes, not endanger them

Fluorescein angiography image of leaking blood vessels
Sickle Cell Disease Increases Risk of Retinal Vascular Occlusion

Watch for sudden unilateral vision loss without pain

Approaches to Managing Glaucoma

Pregnant woman in a pharmacy
Managing Glaucoma in Pregnant Patients

Prescribing eye drops is complicated by unknown risk of fetotoxicity and lack of clinical evidence

Pseudoexfoliation glaucoma
A Multifaceted Approach to Managing Pseudoexfoliation Glaucoma

From medication to laser treatment to surgery

Improving Patient Care

Retina
OCT and OCT-A Can Reveal Biomarkers of Preterm Birth in Adults

Prematurity is linked with poorer outcomes of retinal surgery in adulthood

Eye with uveitis
Patients Taking GLP-1 Meds Reduce Risk of Noninfectious Uveitis by About 50%

Study is first to show reduction in autoimmune disease with the common diabetes and obesity drugs

Diabetic retinopathy
Anti-VEGF in the Real World: Who Is at Risk of Vision Loss After Lapse in Treatment?

Study identifies factors that may predict vision outcomes in diabetic macular edema

Optical coherence tomography image showing macular fluid
Real-World Results: High-Dose Aflibercept Reduces Macular Fluid, Maintains Vision in nAMD

New insights on effectiveness in patients previously treated with other anti-VEGF drugs

Neoadjuvant therapy
Novel Neoadjuvant Treatment Trial for Uveal Melanoma

Oral medication may have potential to preserve vision and shrink tumors prior to surgery or radiation

Physician Insights

Festoon (malar mound) under an eye
How to Improve the Appearance of Festoons (Malar Mounds)

Treatment options range from tetracycline injections to fat repositioning and cheek lift

microinvasive glaucoma surgery
How to Get Started With Microinvasive Glaucoma Surgery (Part 1)

7 keys to success for comprehensive ophthalmologists

Microinvasive glaucoma surgery
How to Get Started With Microinvasive Glaucoma Surgery (Part 2)

A primer on MIGS methods and devices

Surgery for diabetic tractional retinal detachment
9 Tips to Ease Fears About Treating Diabetic Tractional Retinal Detachment

The advanced stage of diabetic retinopathy is among the most challenging for retinal surgeons

Using heads-up display during retina surgery
Imaging in the OR: Combining Intraoperative OCT With Heads-Up Display

A look at emerging technology shaping retina surgery

Resources

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