A pooling of data from several PARTNER trials shows that chronic kidney disease was highly prevalent and that TAVR was associated with stable or improved kidney function in a large majority of cases.
The 3,000-patient PROTECTED TAVR trial is large enough to detect a clinical reduction in stroke at 72 hours. And the ongoing WATCH-TAVR trial aims to show whether simultaneous TAVR and Watchman placement is safe and cost-saving.
Findings of better post-TAVR survival in mixed aortic valve disease compared with pure aortic stenosis suggest that hearts already exposed to aortic regurgitation may better tolerate mild post-TAVR regurgitation.
Percutaneous coronary intervention (PCI) at the time of transcatheter aortic valve replacement (TAVR) does not appear to increase TAVR risk, according to pooled results from 11 observational studies. But the safety question isn’t fully settled.
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An analysis of the TVT Registry shows a lower-than-expected stroke rate following transcatheter aortic valve replacement. But it also shows a lack of improvement over time.
Two trials comparing transcatheter (TAVR) with surgical aortic valve replacement in patients at low surgical risk found TAVR to yield equal or better outcomes. While a new indication seems certain, some key questions remain.
A new analysis of the large TVT Registry provides the strongest evidence to date of a prognostic benefit from renin-angiotensin system inhibitor therapy following transcatheter aortic valve replacement.
The next waves of progress in transcatheter aortic valve replacement are likely to involve expanding indications, valve refinements and new accessory treatments.
Our experts outline their vision of ideal changes to the National Coverage Determination for programs performing transcatheter aortic valve replacement. A CMS decision is due in June 2019.
The latest PARTNER 2A analysis finds that worsening RV function is much more common after SAVR than TAVR. And it predicts greater risk for poor outcomes regardless of procedure type.