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Cleveland Clinic Cancer Advances: 2025 Highlights

Welcome to the new spotlight edition of Cancer Advances, exploring the latest research and clinical advances in hematology and oncology.

Dr. Raza

Dual Bispecifics May Redefine Management of Extramedullary Myeloma

Phase 2 study brings pivotal advances in treatment efficacy and safety for the most challenging-to-treat population

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Highlights in Hematology

CAR T-cell therapy illustration
First-Ever U.S. Trial of CAR T-Cell Therapy for Relapsed/Refractory AL Amyloidosis

Early results show patients experiencing deep and complete response

Dr. Gerds with a patient
Positive Results from Phase 3 Trial of Pelabresib + Ruxolitinib for JAK Inhibitor-Naive Myelofibrosis

Combination therapy doubles the number of meaningful spleen volume responses over monotherapy

monoclonal antibody illustration
New Essential Thrombocythemia Treatment Appears to Address Underlying Disease

Phase 1 study found mutant calreticulin-specific monoclonal antibody brings promising results with no dose-limiting toxicities

Young People With Cancer

Physician speaking with patient
Scoring Tool Predicts Colorectal Cancer Risk in Younger Adults

Simple score uses clinical factors to identify patients who might benefit from earlier screening

Child and caregiver hands on top of hospital bed
Palliative Care Addresses an Unmet Need in Sickle Cell Disease

Integrated care model reduces length of stay, improves outpatient pain management

Case Studies

Pathology image
Patient Case Study: Second Opinion Reveals Misdiagnosed Cancer

Patient receives liver transplant and a new lease on life

network of nerves on the side of the face
Preemptive Facial Nerve Rewiring in the Management of Facial Nerve Tumor: A Case Study

Novel approach begins reinnervation before tumor resection, preserving a young woman’s smile

PET scan
Case Study: Patient with High-Risk Mantle Cell Lymphoma

Patient with TP53 mutation achieves full response with targeted therapy

CAR T-cell therapy
Case Study: Patient Remains Disease Free Five Years After Allogenic CAR T-Cell Therapy

Patient with quadruple refractory multiple myeloma achieves complete response with cell therapy

Care Insights and Community Education

World map
Breaking Barriers to Cancer Care: Cleveland Clinic’s Global Approach

A multi-pronged strategy for tackling cancer access problems

church bus tour
Novel Community Campaign Increases Venous Thromboembolism Awareness

National Blood Clot Alliance collaborates with faith-based organizations on first-of-its-kind church bus tour

Head & neck image contouring
Subspecialty Peer Review Improves Consistency, Quality and Safety in Head and Neck Radiation Therapy

Program reduces major contour changes and variations in organ-at-risk dosing across health system

Deintensifiction

Dr. Cherian
De-intensifying Radiation Therapy in Low-Risk Breast Cancer

Ultra-Hypofractionated Whole Breast Irradiation and Partial Breast Irradiation Reduce Many Toxicities

Surgeon
Potential for Deintensification of Surgical Interventions in Low-Risk Breast Cancer

Reconsidering axillary lymph node dissection as well as depth of surgical margins

Innovations Improving Patient Care

Photonic sensor
Novel Partnership Aims to Advance ctDNA Testing in Non-Small Cell Lung Cancer

Cleveland Clinic, the University of Minnesota and University of Cambridge receive $1M grant to develop point-of-care biosensor for early detection and treatment personalization

Chris Weight typing into laptop in office
Artificial Intelligence Tool Informs Prostate Cancer Management

AI histologic classifier reliably predicts clinical risk in men post-prostatectomy

X-ray of pelvis implant
3D-Printed Pelvis Implant Restores Function After Sarcoma Resection

Personalized reconstruction is an alternative to leg amputation or flail limb

Dr. Jame Abraham
Trastuzumab Deruxtecan Improves Invasive Disease-Free Survival of Early-Stage HER+ Breast Cancer by 53%

International study supports change in clinical care in post-neoadjuvant setting

Resources

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